This spitz nevus is 1 centimeter in diameter and is on a childs shoulder. Spitzoid melanoma is diagnosed on skin biopsy of an enlarging nodule. Melanoma can have similar features to both classic and atypical spitz nevi and must be ruled out in all cases. These lesions are by nature benign, but their features can sometimes make. The epub format uses ebook readers, which have several ease of reading features. All structured data from the file and property namespaces is available under the creative commons cc0 license. The spitz nevus is a benign melanocytic lesion with clinical and histopathological features similar to those of melanoma. Spitz nevus is an acquired melanocytic lesion, which generally develops in children and adolescents, although it is not rare in adults. Both classic and atypical spitz nevi are uncommon melanocytic lesions usually presenting in children and adolescents. A type of melanocytic nevus, it affects the epidermis and dermis it is also known as an epithelioid and spindlecell nevus, and misleadingly as a benign juvenile melanoma. A spitz nevus is a melanocytic neoplasm of epithelioid andor spindle cells that usually appears in childhood. There is debate as to whether the pscnor is an entity in its own right or whether it is a variation of a spitz naevus.
The nevus was composed of broad but laterally demarcated compound proliferation of enlarged fusiform and epithelioid melanocytes, with florid pagetoid scatter above the junction. Many authors consider it as an unusual variant of the tumor described by sophie spitz in 1948. In this context, labels, such as spitz nevus, atypical spitz nevus, atypical spitz tumor, and spitzoid melanoma. Indpendently of age, sex, location, palpability, and pigmentation of the lesion, most spitz nevi tend to go through spontaneous involution over time. Spitz nevi usually appear in children and young adults, they peak during the second and third decades of life, and are only rarely seen from the seventh decade to the ninth decade.
Within the last few years, sentinel lymph node biopsy slnb has been proposed as a useful tool in the management of melanocytic neoplasms of uncertain behavior, such as the atypical spitz nevus. Spitz nevus is a melanocytic tumor considered a variant of the composed melanocytic nevus. While these moles may develop in adults, they are more common in children and adolescents. Agminated spitz nevi on a hyperpigmented macule actas dermo. Spitz nevi can be very difficult to distinguish from melanoma, as a result treatment tends to involve excision of the nevi. It also may be called a nevus, spitz lesion, juvenile melanoma, benign juvenile melanoma, or spindle and epithelioid cell nevus of reed. A spitz nevus is typically under 1 centimeter in diameter, firm, raised, and pink or reddishbrown. A comparative study of spitz nevus and nodular malignant. The pigmented spindle cell naevus of reed pscnor is a variant of a compound or occasionally a junctional naevus. However, it may resemble a malignant melanoma clinically and microscopically, so spitz naevi are often excised as a precaution. Spitz nevi usually present as solitary, pinktored plaques or nodules, but pigmented spitz nevi are also commonly.
This page was last edited on 22 october 2018, at 15. Spitz naevi are typically domeshaped red, reddishbrown or darker bumps or blisters up to one or two centimeters in diameter. Again, spitz tumor is used as the umbrella term for the entire, category of lesions. It may be smooth or scaly and usually appears on the face, particularly the cheeks. Although it can look like a serious form of skin cancer called melanoma, a spitz nevus lesion isnt. They tend to grow quickly initially, but then stabilize or even disappear after a period of time.
Pdf spitz and reed nevi, also called spindle andor epithelioid cell nevi, are a special group of melanocytic. Common terms, including mole, birthmark, and beauty mark, are used to describe nevi, but these terms do not distinguish. Spitz naevi have also been called juvenile melanomas because they resemble malignant tumors clinically and microscopically, but the spitz naevi are actually benign. May involve epidermis and dermis as a confluent mass. Spitz nevi are melanocytic proliferations characterized by spindled andor.
It was first described in 1948 but great controversy still remains today. Spitz nevus are noncancerous skin lesions that tend to be domeshaped, red, reddishbrown or dark colored. Spitz nevus with one or more aspects of atypia atypical spitz nevus 3. Spitz nevi the plural of nevus are not harmful, but they can be difficult to differentiate from melanoma, even for experts.
The classic spitz nevus typically is benign and has characteristic clinical and histologic features. It is a group of nevus cells in the layers of the skin. Files are available under licenses specified on their description page. They usually appear before the age of 20, however, they can appear on adults as well.
Melanocytic spitzoid lesions include benign spitz nevus, atypical spitz. Giant recurrence of a multiple agminated spitz nevus. An update on molecular alterations in melanocytic tumors with. Spitz nevus genetic and rare diseases information center. Among the various types of melanocytic nevi, spitz nevi are the most controversial due to their morphologic vicinity to melanoma. Transepidermal elimination of nevus cells in spindle and. A spitz naevus or spitzs nevus is an uncommon type of mole melanocytic naevus. Discussion the occurrence of the intraoral spitz nevus is very rare, having been reported previously in the international literature only twice. Nevus spilus ns, also known as speckled lentiginous nevus, is characterized by background cafe au laitlike lentiginous melanocytic hyperplasia speckled with small, 1 to 3mm, darker foci. Moreover, in our estimation, those designations, and variants of them, like atypical spitzs lesion, atypical dermal melanocytic lesion with features of spitzs nevus. In contrast, the atypical spitz nevus has an unknown clinical prognosis, and its clinical and histologic traits are loosely defined. Most spitz nevi occur in a persons first 20 years of life. Jun 11, 2010 spitz nevus is an acquired melanocytic lesion, which generally develops in children and adolescents, although it is not rare in adults. These lesions are termed atypical spitz nevitumors and there is currently a lack of objective criteria for.
Transepidermal elimination of nevus cells of a spitz nevus was also present in one of the six cases reported by yuki et al. The anomaly is usually referred to as benign juvenile melanoma, sometimes as spitzs nevus, and, by some histopathologists, as spindle and epithelioid cell nevus. Nino m, brunetti b, delfino s, panariello l, russo d. Spitz nevi the plural of nevus are not harmful, but they can be difficult to differentiate from melanoma. Nevus or nevi if multiple is a nonspecific medical term for a visible, circumscribed, chronic lesion of the skin or mucosa. Jan 08, 2018 melanocytic nevi with features of spitz nevi and clarksdysplastic nevi sparks nevi. A spitz naevus or spitz s nevus is an uncommon type of mole melanocytic naevus. A spitz nevus is often is pink and somewhat domeshaped.
Volume 111, issue 1, januaryfebruary 2020, pages 719. It is usually benign, but the clinical presentation and histopathology sometimes mimic melanoma. This is a pdf file of an unedited manuscript that has. However, it is often difficult for a clinician to be certain that the condition is a spitz nevus. Spitz nevi, in their majority approximately 66% are compound 8, 510% junctional and 1220% dermal.
A spitz nevus is a melanocytic neoplasm of epithelioid andor. Clinical criteria of spitz nevus and malignant melanoma criterion spitz nevus malignant melanoma symmetry yes no, except for early lesions and the rare nodular form of melanoma diameter naevus. The name juvenile melanoma is generally no longer used as it is neither a melanoma, nor does it occur only in children. Although it can look like a serious form of skin cancer called melanoma, a. Oct 09, 2014 spitz nevus are rare, benign moles that closely resemble melanoma. A spitz nevus is a rare type of skin mole that usually affects young people and children. Histologically and cytologically, spitzoid melanomas share common features with spitz naevi. There is debate as to whether the pscnor is an entity in its own right or whether it is a variation of a. In part ii of this cme, we will maintain the terminology defined in part i for purposes of continuity. They usually develop on the face or limbs of young children. Sabater marco v, escutia munoz b, morera faet a, roig mm, botella estrada r.
Atypical spitzs nevus, malignant spitzs nevus, and me. All the histological subtleties and variations of the condition are still not fully appreciated and some of them are still being misinterpreted as those of malignant melanoma. Spitz nevus and other spitzoid tumors in children part 1. A spitz nevus is an unusual type of mole that looks similar to melanoma but isnt. A spitz nevus can look very much a like a serious kind of skin. Nevus of large spindle andor epithelioid cells spitzs nevus. Nevus melanociticos adquiridos pdf download 11lyv7. Pictures of skin diseases and problems spitz nevus. Theoretically, a spitz nevus does not removing because it is a benign grown like other moles. The natural evolution of melanocytic nevi is a complex, multifactorial process involving constitutional and environmental factors. Sa croissance est rapide, en quelques mois, avant une stabilisation. Histologically, spitz nevus has been subdivided into.